Linkage Analysis and Gene Mapping

One major task of genetic studies is to construct the genetic map through
linkage analysis, and then locate the genetic loci of important traits on the
constructed linkage maps, identify favorable alleles which are of values to
human beings, and investigate their biochemical pathways from genotype to
phenotype. This book presents the linkage analysis and gene mapping
methodologies, which are applicable to self-pollinated, cross-pollinated, and
asexual propagated species, and genetic populations derived from two
homozygous parents, two heterozygous parents, and multiple homozygous parents.
Chapter 1 in this book begins with genetic mating designs and various types of
genetic populations, followed by the structure of commonly used populations
and analysis methods of phenotypic data. In chapters 2 and 3, estimation of
recombination frequency and construction of linkage map are introduced for
twenty bi-parental populations. Chapter 4 deals with two classical gene
mapping methods, where no background control is considered, while chapters 5
and 6 describe the inclusive composite interval mapping (ICIM) with background
control. Chapter 7 is focused on populations derived from two heterozygous
parents, which can be two individuals in a random mating population, two
clonal cultivars, or two single crosses from four homozygous inbred lines.
Chapter 8 provides knowledge on the pure-line progeny populations derived from
four to eight homozygous parents. The last two chapters covers populations,
methods and commonly asked questions in genetic mapping which cannot be
included previously. This book is intended for readers working on plant and
animal genetics, population and quantitative genetics, and plant and animal
breeding.